2H-Pyran-3-ol, tetrahydro-2,2,6-trimethyl-6-vinyl-

2H-Pyran-3-ol, tetrahydro-2,2,6-trimethyl-6-vinyl- - Names and Identifiers

Name	2,2,6-Trimethyl-6-Vinyltetrahydro-2H-Pyran-3-OL
Synonyms	Epoxylinalol linalool oxide pyranoside 6-ETHENYL-2,2,6-TRIMETHYLOXAN-3-OL 2,2,6-Trimethyl-6-Vinyltetrahydro-2H-Pyran-3-OL 2,2,6-TRIMETHYL-6-VINYLTETRAHYDRO-2H-PYRAN-3-OL 3-Hydroxy-2,2,6-trimethyl-6-vinyltetrahydropyran 2H-Pyran-3-ol, tetrahydro-2,2,6-trimethyl-6-vinyl- 2H-Pyran-3-ol, 6-ethenyltetrahydro-2,2,6-trimethyl- 3-Hydroxy-2,2,6-trimethyl-6-vinyltetrahydropyran Linalool Oxide Pyranoid
CAS	14049-11-7
EINECS	237-889-1

2H-Pyran-3-ol, tetrahydro-2,2,6-trimethyl-6-vinyl- - Physico-chemical Properties

Molecular Formula	C10H18O2
Molar Mass	170.25
Density	0.988±0.06 g/cm3(Predicted)
Boling Point	98°C/10mmHg(lit.)
Flash Point	100°C(lit.)
JECFA Number	2135
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Gel
Specific Gravity	0.989
Color	White to Off-White
pKa	14.43±0.60(Predicted)
Storage Condition	Amber Vial, -20°C Freezer, Under inert atmosphere

2H-Pyran-3-ol, tetrahydro-2,2,6-trimethyl-6-vinyl- - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

2H-Pyran-3-ol, tetrahydro-2,2,6-trimethyl-6-vinyl- - Introduction

2,2, +, often referred to simply as TEMPO (n-alkyl-2, 2,6, 6-tetramethylpiperidine oxide), is an important organic synthetic reagent.

Nature:
TEMPO is a solid with a colorless or pale yellow appearance. It is soluble in water, ethanol, ether and many other organic solvents at room temperature. It has a stable free radical structure and has strong oxidation.

Use:
TEMPO is widely used in organic synthesis, mainly for catalytic oxidation reaction. It is often used for oxidation of alcohols to ketones, oxidation of allyl compounds, oxidation of aldehydes to acids and other reactions. In addition, TEMPO can also be used to catalyze the oxidation of amines, the selective oxidation of sugar alcohols and other small organic molecules.

Preparation Method:
The regular preparation method of TEMPO is to oxidize piperidine to obtain Piperidine Oxide, and then Methyl methanesulfonate is used to introduce alkyl group from Piperidine Oxide to obtain TEMPO. The specific preparation method can refer to the relevant chemical literature.

Safety Information:
TEMPO has no obvious toxicity to human body and environment under general conditions, but it is an oxidant and has certain risks. During use, avoid skin contact and avoid inhalation or ingestion. Adequate ventilation and the use of personal protective equipment such as gloves and safety glasses are required. In addition, TEMPO should be stored in a dry, ventilated place, away from fire and flammable materials. The use and storage of TEMPO should be carried out in accordance with the relevant safe operation guidelines.

Last Update：2024-04-09 20:52:54